International Clinical Trials Day: Data Centric Clinical Research

Wien, 20.05.2024 – Text: Catarina Carrão International Clinical Trials Day In May 2005, the European Clinical Research Infrastructures Network (ECRIN) begun celebrating the International Clinical Trials Day. This celebration yearly brings together patients, health policy actors, health authorities, clinical researchers, health professionals and citizens from across Europe and beyond to discuss issues related to multinational […]

Implementing the EU Health Technology Assessment Regulation (EU HTAR)

Wien, 24.04.2024 – Text: Catarina Carrão The development of health technologies is a key driver of economic growth and innovation in the European Union (EU), since health technologies constitute an innovative sector of the economy and form part of an overall market for healthcare expenditure that accounts for 10 % of the EU gross domestic […]

EU CTR: Transparency

Wien, 15.04.2024 – Text: Catarina Carrão In the end of January 2022, the EU CTR (EU/536/2014) came into effect within the European Union (EU), replacing the EU Clinical Trials Directive (2001/20/ EC). Under the EU CTR, a new EU database – the Clinical Trials Information System (CTIS) was created to provide a single-entry point for […]

EU MDR and The Need For Clinical Evidence

Wien, 12.03.2024 – Text: Catarina Carrão Since the establishment of the EU Medical Devices Regulation (MDR EU 2017/745), Notified Bodies (NBs) have their hands full evaluating the clinical evidence for such products as a critical step for manufacturers to renew or obtain a green door to the European Economic Area (EEA) market. Clinical evaluation: where […]

From EMA for Pharma SMEs: Updated User Guide

Wien, 15.02.2024 – Text: Catarina Carrão On the 23rd of January 2024, the European Medicines Agency (EMA) released a major revision of its user guide for micro, small and medium-sized enterprises (SMEs) in the pharmaceutical sector. The revised guide offers a comprehensive view on the European Union (EU) legislative framework for medicines, outlining requirements for the development and authorization of medicines for human use. Take a look at the […]

EUDAMED Gestalt

Wien, 17.01.2024 – Text: Catarina Carrão EUDAMED: basics The European database on medical devices (EUDAMED) is an information technologysystem being built and implemented by the European Commission (EC) to fulfil many of the obligations of the Medical Device Regulation (MDR EU 2017/745) and the In Vitro Diagnostic Medical Device Regulation (IVDR EU 2017/746). It serves a fundamental […]

How does the EU AI Act influence clinical trial development?

Wien, 20.12.2023 – Text: Catarina Carrão The EU AI Act The Council presidency and the European Parliament have agreed on a provisional agreement on the proposal for harmonized rules on Artificial Intelligence (AI), known as the AI Act. The draft regulation aims to guarantee the safety and adherence to fundamental rights and values for AI systems in the European Union […]

6th November 2023: Reform of the European Union (EU) Pharmaceutical Legislation

Wien, 06.11.2023 – Text: Catarina Carrão Pharmaceutical Legislation Revision: objectives In April 2023, the European Commission (EC) has adopted a proposal for a new Directive and a new Regulation, which revises and replaces the existing general pharmaceutical legislation.1 The purpose is to create a future proof regulatory framework that supports the industry in promoting research and technologies to reach patient’s needs faster, while […]

01. Oktober 2023: Decentralized Clinical Trials and the use of Digital Health Technologies

Wien, 01.10.2023 – Text: Catarina Carrão With the impact of the COVID-19 pandemic, Decentralized clinical trials (DCTs) and digital health technologies (DHTs) gained a momentum in medical research, allowing for clinical study participants to remotely partake in trials using state-of-the-art DHTs.1-3 What are Decentralized Clinical Trials? According to Dr. Leonard Sacks, associate director for clinical […]

21. August 2023: Pragmatic Clinical Trials

Gouya Insights Clinical Development Logo

Wien, 21.08.2023 – Text: Catarina Carrão Schwartz and Lellouch pragmatic views The Merriam-Webster dictionary defines Pragmatism has a practical approach to problems and affairs.1 In relation to clinical trials, pragmatism surfaced in 1967 with an article from Schwartz & Lellouch, due to concerns that many trials did not adequately inform practice because they were optimized to determine efficacy.2 At the time, authors […]